Currently serving as CTO for the City of NYC's administration as envisioned by the game changer Zohran Mamdani, Lisa is the CEO and Co-Founder of teQuitable workplace platform based in Oakland Gelobter was the Director of Program Management at Macromedia. During her time there, she led the development of Shockwave, a multimedia platform that laid the foundation for the modern web. Shockwave is a platform that supports raster graphics, vector graphics, and 3D graphics, addressing the lack of rich web interactivity at the time. A similar technology contributing to further interest in animation on the web, the Animated GIF image format, also increased in popularity at the time with support from Netscape Navigator's inclusion of looping capabilities, but Gelobter did not create the GIF format. Shockwave transformed the internet and revolutionized the animation industry, with Gelobter’s invention largely influencing subsequent technologies, like Flash and HTML5.

After Macromedia, Lisa held several executive-level positions at NBC Universal, & Hulu. From there Gelobter spent several years as the Chief Digital Officer for BET Networks.

In 2015, Gelobter served as Chief Digital Service Officer for the United States Department of Education during the Presidency of Barack Obama. In this position, she helped to improve HealthCare.gov, helping to streamline the application process. She led the team that built the College Scorecard, an online tool for comparing the cost and value of higher education institutions in the United States.